Molecular profiling of Adolescent Idiopathic Scoliosis: toward a comprehensive understanding of ais aetiology
نویسندگان
چکیده
Introduction The adolescent idiopathic scoliosis (AIS) is the most common deformity arising during childhood. Although its aetiology remains unknown, we have demonstrated a differential dysfunction of melatonin signalling through Gi proteins in osteoblasts isolated from AIS patients, leading to their stratification into three functional subgroups. Herein we examine the molecular profiles of these AIS groups using the functional classification developed by Moreau et al.
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Evaluation of Patient Outcome and Satisfaction after Surgical Treatment of Adolescent Idiopathic Scoliosis Using Scoliosis Research Society-30
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Introduction Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity of unknown aetiology and extreme variability, occurring at least in genetically predisposed children. We previously demonstrated a differential dysfunction of melatonin signaling through Gi proteins in osteoblasts from AIS patients, leading to stratification of patients into three functional subgroups. Herein we ex...
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